UbiBrowser is a resource of known and predicted human ubiquitin ligase (E3) - substrate interaction network.
The E3-substrate interactions are derived from six data sources: mannual cruration, protein ortholog, protein domain, protein motif and network topology.
A computational framework is used to to combine multiple biological evidences to generate a confidence score using Naïve Bayesian Network. 397,496 predicted and mannually crurated human E3-substrate can be explored in the current version. More..
UbiBrowser has been developed at Beijing proteome research center (BPRC).
Browser compatibility: we support the latest versions of the Chrome, Firefox, Opera, Safari and Internet Explorer (version 10 and 11).
Chrome is the recommended browser.
Notice: UbiBrowser will be moved to new url: http://ubibrowser.ncpsb.org.cn
Comments and questions please send e-mail to liyang_bprc@163.com
#2015.04.01 UbiBrowser was onlined at Apr.1 2015
#2015.07.01 UbiBrowser can be used to predict the substrates for a query E3.
#2017.08.24 The article of UbiBrowser was published on Nature Communications.
This work is funded by the:
Program of International S&T Cooperation (2014DFB30020)
National Natural Science Foundation of China (31271407)
Chinese National Key Program of Basic Research (2012CB910300)
   
   
Number of all E3-substrate interactions | 380,546 |
Number of E3-substrate interactions from literature | 1,315 |
Number of predicted High confidence E3-substrate interactions | 14,419 |
Number of predicted E3 recognizing motifs | 10,480 |
Number of predicted E3 substrate interacting domain pairs | 3,856 |